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Two genes in an organism have a Synthetic Sickness Lethality (SSL) interaction, if their joint deletion leads to a lower than expected fitness. Synthetic Gene Array (SGA) is a technique that helps in identifying SSL values for pairs of genes in a given set of genes. SSL interactions are useful to discover the co-expressed gene groups in the regulatory and signaling networks. Also, they are used...
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ژورنال
عنوان ژورنال: Journal of Perinatology
سال: 2011
ISSN: 0743-8346,1476-5543
DOI: 10.1038/jp.2011.52